Dear Hair Restoration Physician,

I am still working thru FUE-Europe 2019 PRP, STEM, FAT, PHOTOMED for hair regrowth lectures ( regen-list    full-list ) to summarize take-aways.

The 1st three lectures on the regen list were:

1 (Insalaco) Platelet Lysate: Dr. Chiara Insalaco (prior ref).  Is platelet lysate (PRP + platelet lysis) “better” than PRP?

2 (Cole) Influence of Growth Factor Concentration and Amniotic Membrane on Dermal Papilla: Dr. John Cole (prior ref).   Are higher growth factor concentrations “better” ?  (e.g., 8x plt conc vs 2x, 20x plt conc vs 10x, etc.)

3 (Rose) Different PRP Systems, a Comparison: Dr. Paul Rose  What are the differences in PRP prep systems? activation methods? additives (ecm, stem, etc), injection frequency?… and what is “optimal”?

Could an  “optimal” system  produce the “right” combination of platelet concentration + lysis + other additive(s) (stem, exosome, ecm, amniotic membrane, etc.) and

RESULT IN INCREASED HAIR GROWTH RATE? (modified hair formation animation to simulate increased hair-growth-rate treatment effect)

AND/OR INCREASED HAIR SHAFT THICKNESS? (photoshop-enlargement of dermal papilla to produce a thicker hair)

We are going to try to find out as LaserCap Company is setting up wet lab to grow hair follicles in-vitro (Philpot 2018     Raposio 2016) and our PRP Cell Lab can already produce PRP in the 2x to 20x range, along with associated platelet lysate by freeze-thaw method –  e.g., links below show 10x PRP prep where we produced platelet lysate (2 million platelets down to 571k platelets after freeze-thaw; resulting growth factor concentrations in plasma to be measured by ELISA; platelet lysate plasma from 2x to 20x to be used as culture media to look for in-vitro hair length increase relative to control and/or changes in shaft thickness measure by laser micrometer (HAIRSCAN) method.

Platelet Lysate from PRP Cell Lab:

link 10x plt shows 192k to >2m then down to 271 x 2 = 542k plt  after 1st freeze-thaw (around 75% lyse)

link 10x plt before freeze-thaw

link 10x plt after freeze-thaw  shows platelet aggregation with  >2m plt down to 271 x 2 = 542k plt (around 75% lyse)

link video overview

And, of course, we will test direct photomed effects on in-vitro hair growth per rx.lasercap.us  as well as indirect effects by photostimulation of PRP preps prior to their in-vitro use [all part of our ‘prp + photomed for hair regrowth’ registry trial planning; see labs.lasercap.us].

Cheers

Mike

Ps our PRP Cell Lab is open to perform cell counts with differentials on your PRP preparations – e.g., we can perform the same set of whole blood and prp cell counts with differentials as this $2000/prp-certification private lab, at no cost to physicians who purchase LaserCap® devices for use with their patients, and we include microscopic exam (see prp.lasercap.us; clinical relevance of microscopic to be determined, however it is an interesting visual of the prp prep). 

Michael Rabin, MD, MBA, CEO
LaserCap Company 
26 Alpha Park 
Highland Heights, OH 44143 
+1 440-241-1846 
 
About LaserCap® Company – Transdermal Cap, Inc. was formed in 2006 by co-inventors Michael Rabin, MD and M.I.T.-trained optical physicist David Smith, PhD, in collaboration with Harvard-based photomedicine expert Michael Hamblin, PhD and internationally acclaimed hair restoration physician Robert Haber, MD, to develop innovative light-based devices for the Global Beauty & Health Industries. Its first commercial product is LaserCap for women with thinning hair or at risk for thinning hair, a condition that affects up to 50% of adult women. Patents pending, Copyright 2009 Transdermal Cap, Inc. 
 
 

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